Intralymphatic Injections as a New Administration Route for Allergen-Specific Immunotherapy
نویسندگان
چکیده
منابع مشابه
Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial.
The only causative treatment for IgE-mediated allergies is allergen-specific immunotherapy. However, fewer than 5% of allergy patients receive immunotherapy because of its long duration and risk of allergic side effects. We aimed at enhancing s.c. immunotherapy by direct administration of allergen into s.c. lymph nodes. The objective was to evaluate safety and efficacy compared with conventiona...
متن کاملAllergen-specific intralymphatic immunotherapy in human and animal studies
Clinical trials of intralymphatic immunotherapy (ILIT) have been performed to overcome the limitations of long-term therapy and the local or systemic hypersensitivity reactions in conventional allergen-specific immunotherapy, including subcutaneous or sublingual immunotherapy. Additionally, several animal studies of ILIT have been conducted in the form of translational or veterinary research. W...
متن کاملLung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy
Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...
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these were similar between all groups.When comparisons were made between the groups, these areas showed statistically significant differences: 1) Practitioners who see more patients with EoE more frequently were more likely to perform testing for immediate hypersensitivities to aeroallergens and foods. 2) Practitioners who participate more often in workshops were less likely to perfrom patch te...
متن کاملIntralymphatic immunotherapy
PURPOSE OF REVIEW IgE-mediated allergy can be treated by subcutaneous allergen-specific immunotherapy (SCIT). However, the percentage of allergic patients undergoing SCIT is low, mainly due to the long duration of the therapy and the risk of severe systemic allergic reactions associated with the allergen administration. Typically, SCIT requires dozens of subcutaneous allergen injections that st...
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 2009
ISSN: 1423-0097,1018-2438
DOI: 10.1159/000210381